参考文献：

[1]GAO R, STOCK AM. Biological insights from structures of two-component proteins[J]. Annu Rev Microbiol, 2009, 63:133-154.

[2]HIRAKAWA H, KURUSHIMA J, HASHIMOTO Y, et al. Progress Overview of Bacterial Two-Component Regulatory Systems as Potential Targets for Antimicrobial Chemotherapy[J]. Antibiotics (Basel), 2020, 9(10).

[3]WOSTEN MM, PARKER CT, VAN MOURIK A, et al. The Campylobacter jejuni PhosS/PhosR operon represents a non-classical phosphate-sensitive two-component system[J]. Mol Microbiol, 2006, 62(1):278-291.

[4]LIU C, SUN D, ZHU J, et al. Two-Component Signal Transduction Systems: A Major Strategy for Connecting Input Stimuli to Biofilm Formation[J]. Front Microbiol, 2018, 9:3279.

[5]HUYNH TN, STEWART V. Negative control in two-component signal transduction by transmitter phosphatase activity[J]. Mol Microbiol, 2011, 82(2):275-286.

[6]ROWLAND MA, DEEDS EJ. Crosstalk and the evolution of specificity in two-component signaling[J]. Proc Natl Acad Sci U S A, 2014, 111(15):5550-5555.

[7]AGRAWAL R, SAHOO BK, SAINI DK. Cross-talk and specificity in two-component signal transduction pathways[J]. Future Microbiol, 2016, 11:685-697.

[8]SVENSSON SL, DAVIS LM, MACKICHAN JK, et al. The CprS sensor kinase of the zoonotic pathogen Campylobacter jejuni influences biofilm formation and is required for optimal chick colonization[J]. Mol Microbiol, 2009, 71(1):253-272.

[9]MACKICHAN JK, GAYNOR EC, CHANG C, et al. The Campylobacter jejuni dccRS two-component system is required for optimal in vivo colonization but is dispensable for in vitro growth[J]. Mol Microbiol, 2004, 54(5):1269-1286.

[10] APEL D, ELLERMEIER J, PRYJMA M, et al. Characterization of Campylobacter jejuni RacRS reveals roles in the heat shock response, motility, and maintenance of cell length homogeneity[J]. J Bacteriol, 2012, 194(9):2342-2354.

[11]Wösten MM, Wagenaar JA, van Putten JP. The FlgS/FlgR two-component signal transduction system regulates the fla regulon in Campylobacter jejuni. J Biol Chem. 2004 Apr 16;279(16):16214-22.

[12]JOSLIN SN, HENDRIXSON DR. Activation of the Campylobacter jejuni FlgSR two-component The Campylobacter jejuni PhosS/PhosR operon represents a non-classical phosphate-sensitive two-component system[J]. Mol Microbiol,system is linked to the flagellar export apparatus[J]. J Bacteriol, 2009, 191(8):2656-2667.

[13]GOODMAN KN, POWERS MJ, CROFTS AA, et al. Campylobacter jejuni BumSR directs a response to butyrate via sensor phosphatase activity to impact transcription and colonization[J]. Proc Natl Acad Sci U S A, 2020, 117(21):11715-11726.

[14]RAPHAEL BH, PEREIRA S, FLOM GA, et al. The Campylobacter jejuni response regulator, CbrR, modulates sodium deoxycholate resistance and chicken colonization[J]. J Bacteriol, 2005, 187(11):3662-3670.

[15]GARENAUX A, GUILLOU S, ERMEL G, et al. Role of the Cj1371 periplasmic protein and the Cj0355c two-component regulator in the Campylobacter jejuni NCTC 11168 response to oxidative stress caused by paraquat[J]. Res Microbiol, 2008, 159(9-10):718-726.

[16]PARK M, HWANG S, RYU S, et al. CosR Regulation of perR Transcription for the Control of Oxidative Stress Defense in Campylobacter jejuni[J]. Microorganisms, 2021, 9(6).

[17]Zhang Z, Yan Y, Pang J, Dai L, Zhang Q, Yu EW. Structural basis of DNA recognition of the Campylobacter jejuni CosR regulator. mBio. 2024 Mar 13;15(3):e0343023.

[18]LI X, REN F, CAI G, et al. Investigating the Role of FlhF Identifies Novel Interactions With Genes Involved in Flagellar Synthesis in Campylobacter jejuni[J]. Front Microbiol, 2020, 11:460.

[19]BALABAN M, JOSLIN SN, HENDRIXSON DR. FlhF and its GTPase activity are required for distinct processes in flagellar gene regulation and biosynthesis in Campylobacter jejuni[J]. J Bacteriol, 2009, 191(21):6602-6611.

[20]REN F, LEI T, SONG Z, et al. Could FlhF be a key element that controls Campylobacter jejuni flagella biosynthesis in the initial assembly stage?[J]. Microbiol Res, 2018, 207:240-248.

[21]BURNHAM PM, HENDRIXSON DR. Campylobacter jejuni: collective components promoting a successful enteric lifestyle[J]. Nat Rev Microbiol, 2018, 16(9):551-565.

[22]KUMAR A, GANGAIAH D, TORRELLES JB, et al. Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni[J]. World J Gastroenterol, 2016, 22(33):7402-7414.

[23]CROFTS AA, POLY FM, EWING CP, et al. Campylobacter jejuni transcriptional and genetic adaptation during human infection[J]. Nat Microbiol, 2018, 3(4):494-502.

[24] VAN MOURIK A, BLEUMINK-PLUYM NMC, VAN DIJK L, et al. Functional analysis of a Campylobacter jejuni alkaline phosphatase secreted via the Tat export machinery[J]. Microbiology (Reading), 2008, 154(Pt 2):584-592.

[25]SVENSSON SL, HUYNH S, PARKER CT, et al. The Campylobacter jejuni CprRS two-component regulatory system regulates aspects of the cell envelope[J]. Mol Microbiol, 2015, 96(1):189-209.

[26]ELMI A, NASHER F, DORRELL N, et al. Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing[J]. Front Cell Infect Microbiol, 2020, 10:607704.

[27] BRAS AM, CHATTERJEE S, WREN BW, et al. A novel Campylobacter jejuni two-component regulatory system important for temperature-dependent growth and colonization[J]. J Bacteriol, 1999, 181(10):3298-3302.

[28] LUETHY PM, HUYNH S, PARKER CT, et al. Analysis of the activity and regulon of the two-component regulatory system composed by Cjj81176_1484 and Cjj81176_1483 of Campylobacter jejuni[J]. J Bacteriol, 2015, 197(9):1592-1605.

[29] Ruiz N, Hendrixson DR. A Campylobacter jejuni sensor phosphatase-driven two-component system integrates metabolic phosphodonors as cues in signal transduction. Proc Natl Acad Sci U S A. 2025 Sep 30;122(39):e2512446122.

[30] Ruiz N, Xing J, Zhulin IB, Brautigam CA, Hendrixson DR. The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction. mBio. 2025 Feb 5;16(2):e0327824.